August 2007

Multivariate data processing of spectral images: The Ugly, the Bad and the True

Spectroscopy

The paper demonstrates the difference between 'pretty' and 'true' Raman chemical images, and how to achieve true and pretty Raman chemical images.

June 2006

Raman Imaging: Defining the Spatial Resolution of the Technology

Spectroscopy, supplement Raman

Chemical images of polystyrene beads on silicon acquired using Raman mapping and image processing are reviewed. The effects of the objective on the quality of the final image, particularly its magnification and numerical aperture, and the step size of the map, are discussed as well.

August/
September 2005

Spectroscopic imaging for the life sciences
- more than just a pretty picture

Spectroscopy Europe Life Science supplement

It has long been a major goal of scientists to understand the many complex processes taking place within living organisms, ranging from microscopic species such as bacteria and viruses at one extreme, through to the human at the other. This article shows that micro-spectroscopic imaging is a key technique for biological research.

June 2005

Spectroscopy Solutions for Materials Analysis

Spectroscopy

Raman and EDXRF Chemical Imaging for Formulation Process Development and Quality Control Compounds of magnesium and calcium are common components of pharmaceutical formulations.

Spectroscopic imaging can provide a complete understanding of a formulation. This paper compares two spectral imaging techniques - energy dispersive X-Ray Fluorescence (EDXRF) microscopy and Raman microscopy.

Spring 2005

Biopharma Imaging and Analysis - Advancing Towards a More Detailed Picture of Chemistry

European Biopharmaceutical Review

There is a wealth of analytical and imaging techniques available for the measurement of biopharma samples. The samples themselves can be wide ranging and take numerous forms: single cells, tissues, crystals or blended formulations. To study and develop such samples many techniques, including fluorescence microscopy, NIR imaging, AFM and SEM, have been used.

June 2005

Refined Raman Spectroscopy
-Bringing new insight into industrial processes

Optics & Photonics News

Fibre probes and ease of use make Raman spectroscopy systems attractive for monitoring process control in many industries, ranging from pharmaceuticals to petrochemicals. The authors describe the Raman effect and discuss systel and monitoring basics.

April 2005

A new dimension in cell imaging
-Combining chemical and spatial information

BIOforum Europe

There are many microscopic imaging techniques used to investigate the complexities of cell structure, including optical microscopy, confocal laser scanning microscopy, scanning electron microscopy (SEM) and atomic force microscopy (AFM). These techniques provide highly detailed images of the cells, but they fail to characterize the chemistry and composition of the sample under examination. Spectroscopic techniques, however, can do just that, and in particular Raman micro-spectroscopy is fast becoming established for probing cellular biochemistry on the micron scale.

June 2005

Micro-spectroscopy - shedding light on rock formation

Spectroscopy Europe

Whilst there are many imaging techniques available to a research scientist, the information which is provided is often only of a visual/topographical nature. What they fail to provide is true compositional (chemical/elemental) analysis of the materials. However, microspectroscopic techniques such as Raman or X-Ray Fluorescence (XRF) can fill this gap, allowing highly detailed images to be generated based upon the sample's material composition.